CA9

GENE INFORMATION

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Gene name

CA9 (HGNC Symbol)

Synonyms

CAIX, MN

Description

Carbonic anhydrase IX (HGNC Symbol)

Entrez gene summary

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

p13.3

Chromosome location (bp)

35673853 - 35681156

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000107159 (version 75.37)

Entrez gene

768

UniProt

Q16790 (UniProt - Evidence at protein level)

neXtProt

NX_Q16790

Antibodypedia

CA9 antibodies
 

PROTEIN VIEW

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CA9-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CA9-001 ENSP00000367608
ENST00000378357
Q16790
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