BMPR1A

GENE INFORMATION

? »

Gene name

BMPR1A (HGNC Symbol)

Synonyms

ACVRLK3, ALK3, CD292

Description

bone morphogenetic protein receptor, type IA (HGNC Symbol)

Entrez gene summary

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]

Chromosome

10 (Chromosome progress)

Cytoband

q23.2

Chromosome location (bp)

88516407 - 88684945

Ensembl

ENSG00000107779 (version 73.37)

Entrez gene

657

UniProt

P36894 (UniProt - Evidence at protein level)

neXtProt

NX_P36894

Antibodypedia

BMPR1A antibodies
 

PROTEIN VIEW

? »
 
 
 
BMPR1A-001
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BMPR1A-001 ENSP00000361107
ENST00000372037
P36894
Show all »
Show » Show » 532 60.2 Yes 1