MAP3K8

GENE INFORMATION

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Gene name

MAP3K8 (HGNC Symbol)

Synonyms

c-COT, COT, EST, ESTF, MEKK8, Tpl-2

Description

mitogen-activated protein kinase kinase kinase 8 (HGNC Symbol)

Entrez gene summary

This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

Chromosome

10 (Chromosome progress)

Cytoband

p11.23

Chromosome location (bp)

30722866 - 30750762

Ensembl

ENSG00000107968 (version 73.37)

Entrez gene

1326

UniProt

P41279 (UniProt - Evidence at protein level)

neXtProt

NX_P41279

Antibodypedia

MAP3K8 antibodies
 

PROTEIN VIEW

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MAP3K8-002
 
MAP3K8-003
 
MAP3K8-004
 
MAP3K8-005
 
MAP3K8-006
 
MAP3K8-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP3K8-002 ENSP00000263056
ENST00000263056
P41279
Show all »
Show » Show » 467 52.9 No 0
MAP3K8-003 ENSP00000364470
ENST00000375321
P41279
Show all »
Show » Show » 467 52.9 No 0
MAP3K8-004 ENSP00000409653
ENST00000415139
Q5T857
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Show » 255 29 No 0
MAP3K8-005 ENSP00000391275
ENST00000413724
Q5T853
Show all »
Show » 223 25.1 No 0
MAP3K8-006 ENSP00000364471
ENST00000375322
Q5T854
Show all »
Show » 132 15 No 0
MAP3K8-201 ENSP00000443610
ENST00000542547
P41279
Show all »
Show » Show » 467 52.9 No 0