The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
Most malignant cells were moderately stained. Several cases of endometrial, thyroid and colorectal cancers showed strong immunoreactivity. Testicular and hepatocellular cancers were negative in several cases.
A few cases of colorectal, renal, endometrial and pancreatic cancers showed moderate cytoplasmic and membranous staining. Remaining malignant cells were weakly stained or negative.
Weak to moderate cytoplasmic and occasional membranous immunoreactivity was displayed in several renal cancers along with a few cases of pancreatic, endometrial and colorectal cancers. Remaining malignant cells were in general negative.
Malignant cells exhibited weak to moderate cytoplasmic and occasional membranous immunoreactivity. Thyroid cancers showed strong staining. Several cases of malignant lymphomas and a few cases of testicular cancers were negative.
Validation
Two (or more) antibodies yielding partly similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
