PSMB3

GENE INFORMATION

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Gene name

PSMB3 (HGNC Symbol)

Synonyms

HC10-II, MGC4147

Description

proteasome (prosome, macropain) subunit, beta type, 3 (HGNC Symbol)

Entrez gene summary

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. The 26 S proteasome may be involved in trinucleotide repeat expansion, a phenomenon which is associated with many hereditary neurological diseases. Pseudogenes have been identified on chromosomes 2 and 12. Alternative splicing results in multiple transcript variants [provided by RefSeq, Sep 2013]

Chromosome

17 (Chromosome progress)

Cytoband

q12

Chromosome location (bp)

36908989 - 36920484

Ensembl

ENSG00000108294 (version 73.37)

Entrez gene

5691

UniProt

P49720 (UniProt - Evidence at protein level)

neXtProt

NX_P49720

Antibodypedia

PSMB3 antibodies
 

PROTEIN VIEW

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PSMB3-001
 
PSMB3-002
 
PSMB3-003
 
PSMB3-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PSMB3-001 ENSP00000225426
ENST00000225426
P49720
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Show » Show » 205 22.9 No 0
PSMB3-002 ENSP00000462556
ENST00000584662
J3KSM3
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Show » 107 12.1 No 0
PSMB3-003 ENSP00000462128
ENST00000579729
J3KRR2
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Show » 112 12.6 No 0
PSMB3-006 ENSP00000463198
ENST00000579088
J3QKR3
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Show » 145 16.2 No 0