RPS6KB1

GENE INFORMATION

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Gene name

RPS6KB1 (HGNC Symbol)

Synonyms

p70(S6K)-alpha, PS6K, S6K1, STK14A

Description

ribosomal protein S6 kinase, 70kDa, polypeptide 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]

Chromosome

17 (Chromosome progress)

Cytoband

q23.1

Chromosome location (bp)

57970447 - 58027925

Ensembl

ENSG00000108443 (version 73.37)

Entrez gene

6198

UniProt

P23443 (UniProt - Evidence at protein level)

neXtProt

NX_P23443

Antibodypedia

RPS6KB1 antibodies
 

PROTEIN VIEW

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RPS6KB1-001
 
RPS6KB1-002
 
RPS6KB1-003
 
RPS6KB1-004
 
RPS6KB1-007
 
RPS6KB1-008
 
RPS6KB1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RPS6KB1-001 ENSP00000225577
ENST00000225577
P23443
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Show » Show » 525 59.1 No 0
RPS6KB1-002 ENSP00000384335
ENST00000406116
Q7Z721
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Show » 451 51 No 0
RPS6KB1-003 ENSP00000468058
ENST00000472940
K7ER06
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Show » 140 15.8 No 0
RPS6KB1-004 ENSP00000466562
ENST00000489824
K7EMM2
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52 6 No 0
RPS6KB1-007 ENSP00000464805
ENST00000592726
K7EIM2
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Show » 62 6.9 No 0
RPS6KB1-008 ENSP00000441993
ENST00000443572
F6UYM1
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Show » 502 56.6 No 0
RPS6KB1-201 ENSP00000376744
ENST00000393021
B4DLT4
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Show » Show » 472 53 No 0