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GENE INFORMATION

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Gene name

CYTH1 (HGNC Symbol)

Synonyms

B2-1, D17S811E, PSCD1

Description

cytohesin 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. The encoded protein is 83% homologous to that of CYTH2. [provided by RefSeq, Aug 2008]

Chromosome

17 (Chromosome progress)

Cytoband

q25.3

Chromosome location (bp)

76670130 - 76778379

Ensembl

ENSG00000108669 (version 69.37)

Entrez gene

9267

UniProt

Q15438

neXtProt

NX_Q15438

Antibodypedia

CYTH1 antibodies
 

PROTEIN VIEW

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 « 
 
CYTH1-001
 
CYTH1-002
 
CYTH1-005
 
CYTH1-006
 
CYTH1-009
 
CYTH1-012
 
CYTH1-015
 
CYTH1-016
 
CYTH1-018
 
CYTH1-020
 
CYTH1-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYTH1-001 ENSP00000389095
ENST00000446868
Q15438
Show all »
Show » Show » 398 46.4 No 0
CYTH1-002 ENSP00000465665
ENST00000591455
397 46.4 No 0
CYTH1-005 ENSP00000468433
ENST00000586043
194 22.4 No 0
CYTH1-006 ENSP00000466949
ENST00000590300
86 10 No 0
CYTH1-009 ENSP00000465945
ENST00000591574
11 1.3 No 0
CYTH1-012 ENSP00000465252
ENST00000589296
64 7.6 No 0
CYTH1-015 ENSP00000466512
ENST00000589297
B7Z1T4
Show all »
Show » 339 39.5 No 0
CYTH1-016 ENSP00000465940
ENST00000585509
B7Z1T4
Show all »
Show » 339 39.5 No 0
CYTH1-018 ENSP00000467052
ENST00000589768
272 31.7 No 0
CYTH1-020 ENSP00000465530
ENST00000587308
104 12.2 No 0
CYTH1-201 ENSP00000354398
ENST00000361101
Q15438
Show all »
Show » Show » 398 46.4 No 0