ASIC2

GENE INFORMATION

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Gene name

ASIC2 (HGNC Symbol)

Synonyms

ACCN, ACCN1, ASIC2a, BNaC1, BNC1, hBNaC1, MDEG

Description

acid-sensing (proton-gated) ion channel 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]

Chromosome

17 (Chromosome progress)

Cytoband

q11.2

Chromosome location (bp)

31340105 - 32501983

Ensembl

ENSG00000108684 (version 73.37)

Entrez gene

40

UniProt

Q16515 (UniProt - Evidence at protein level)

neXtProt

NX_Q16515

Antibodypedia

ASIC2 antibodies
 

PROTEIN VIEW

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ASIC2-001
 
ASIC2-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ASIC2-001 ENSP00000225823
ENST00000225823
Q16515
Show all »
Show » Show » 563 62.9 No 2
ASIC2-003 ENSP00000352934
ENST00000359872
Q16515
Show all »
Show » Show » 512 57.7 No 2