CCL2

GENE INFORMATION

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Gene name

CCL2 (HGNC Symbol)

Synonyms

GDCF-2, HC11, MCAF, MCP-1, MCP1, MGC9434, SCYA2, SMC-CF

Description

chemokine (C-C motif) ligand 2 (HGNC Symbol)

Entrez gene summary

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]

Chromosome

17 (Chromosome progress)

Cytoband

q12

Chromosome location (bp)

32582304 - 32584222

Ensembl

ENSG00000108691 (version 73.37)

Entrez gene

6347

UniProt

P13500 (UniProt - Evidence at protein level)

neXtProt

NX_P13500

Antibodypedia

CCL2 antibodies
 

PROTEIN VIEW

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CCL2-001
 
CCL2-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCL2-001 ENSP00000225831
ENST00000225831
P13500
Show all »
Show » Show » 99 11 Yes 0
CCL2-004 ENSP00000462156
ENST00000580907
J3KRT7
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Show » Show » 65 7.1 Yes 0