The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
Malignant tissues were mostly weakly to moderately stained in the cytoplasm. Isolated cases of malignant carcinoids and malignant glioma showed strong positivity. Stomach cancers were mainly weakly stained and malignant lymphomas were mostly negative.
A majority of the malignant cells showed moderate cytoplasmic staining. Several colorectal as well as a few cases of ovarian cancers and cholangiocarcinomas displayed strong cytoplasmic and membranous positivity. Malignant lymphomas, renal, skin, urothelial and lung cancers were weakly stained or negative.
Validation
Two (or more) antibodies yielding partly similar staining patterns which are consistent with gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are consistent with gene/protein characterization data
