DPH1

GENE INFORMATION

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Gene name

DPH1 (HGNC Symbol)

Synonyms

DPH2L, DPH2L1, OVCA1

Description

diphthamide biosynthesis 1 (HGNC Symbol)

Entrez gene summary

Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH1 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[supplied by OMIM, Mar 2008]

Chromosome

17 (Chromosome progress)

Cytoband

p13.3

Chromosome location (bp)

1933404 - 1946724

Ensembl

ENSG00000108963 (version 73.37)

Entrez gene

1801

UniProt

Q9BZG8 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BZG8

Antibodypedia

DPH1 antibodies
 

PROTEIN VIEW

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DPH1-001
 
DPH1-002
 
DPH1-003
 
DPH1-007
 
DPH1-009
 
DPH1-014
 
DPH1-018
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DPH1-001 ENSP00000263083
ENST00000263083
Q9BZG8
Show all »
Show » Show » 443 48.8 No 0
DPH1-002 ENSP00000460431
ENST00000575667
Show » 214 22.9 No 0
DPH1-003 ENSP00000458726
ENST00000570477
Q9BZG8
Show all »
Show » Show » 363 40 No 0
DPH1-007 ENSP00000458838
ENST00000571418
B3KQW7
Show all »
Show » Show » 431 47.3 No 0
DPH1-009 ENSP00000460813
ENST00000571710
Show » 148 16.2 No 0
DPH1-014 ENSP00000467936
ENST00000570833
K7EQQ6
Show all »
Show » 49 5.3 No 0
DPH1-018 ENSP00000476070
ENST00000607788
Show » 103 11.2 No 0