MAP2K6

GENE INFORMATION

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Gene name

MAP2K6 (HGNC Symbol)

Synonyms

MAPKK6, MEK6, MKK6, PRKMK6, SAPKK3

Description

mitogen-activated protein kinase kinase 6 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]

Chromosome

17 (Chromosome progress)

Cytoband

q24.3

Chromosome location (bp)

67410839 - 67539472

Ensembl

ENSG00000108984 (version 73.37)

Entrez gene

5608

UniProt

P52564 (UniProt - Evidence at protein level)

neXtProt

NX_P52564

Antibodypedia

MAP2K6 antibodies
 

PROTEIN VIEW

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MAP2K6-001
 
MAP2K6-004
 
MAP2K6-005
 
MAP2K6-006
 
MAP2K6-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP2K6-001 ENSP00000468348
ENST00000590474
P52564
Show all »
Show » Show » 334 37.5 No 0
MAP2K6-004 ENSP00000467213
ENST00000589647
P52564
Show all »
Show » Show » 278 31.3 No 0
MAP2K6-005 ENSP00000351997
ENST00000359094
68 7.5 No 0
MAP2K6-006 ENSP00000466143
ENST00000589295
K7ELM6
Show all »
Show » 84 9.7 No 0
MAP2K6-008 ENSP00000464916
ENST00000588110
K7EIW3
Show all »
Show » 128 14.4 No 0