PHOX2B

GENE INFORMATION

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Gene name

PHOX2B (HGNC Symbol)

Synonyms

NBPhox, Phox2b, PMX2B

Description

paired-like homeobox 2b (HGNC Symbol)

Entrez gene summary

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. [provided by RefSeq, Jul 2008]

Chromosome

4 (Chromosome progress)

Cytoband

p13

Chromosome location (bp)

41746099 - 41750987

Ensembl

ENSG00000109132 (version 73.37)

Entrez gene

8929

UniProt

Q99453 (UniProt - Evidence at protein level)

neXtProt

NX_Q99453

Antibodypedia

PHOX2B antibodies
 

PROTEIN VIEW

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PHOX2B-001
 
PHOX2B-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PHOX2B-001 ENSP00000226382
ENST00000226382
Q99453
Show all »
Show » Show » 314 31.6 No 0
PHOX2B-002 ENSP00000426733
ENST00000510424
Show » Show » 180 18.8 No 0