NFKB1

GENE INFORMATION

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Gene name

NFKB1 (HGNC Symbol)

Synonyms

KBF1, NF-kappaB, NF-kB1, NFkappaB, NFKB-p50, p105, p50

Description

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Chromosome

4 (Chromosome progress)

Cytoband

q24

Chromosome location (bp)

103422486 - 103538459

Ensembl

ENSG00000109320 (version 73.37)

Entrez gene

4790

UniProt

P19838 (UniProt - Evidence at protein level)

neXtProt

NX_P19838

Antibodypedia

NFKB1 antibodies
 

PROTEIN VIEW

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NFKB1-001
 
NFKB1-002
 
NFKB1-003
 
NFKB1-004
 
NFKB1-005
 
NFKB1-007
 
NFKB1-011
 
NFKB1-013
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NFKB1-001 ENSP00000226574
ENST00000226574
P19838
Show all »
Show » Show » 969 105.4 No 0
NFKB1-002 ENSP00000378297
ENST00000394820
P19838
Show all »
Show » Show » 968 105.4 No 0
NFKB1-003 ENSP00000424790
ENST00000505458
P19838
Show all »
Show » Show » 968 105.4 No 0
NFKB1-004 ENSP00000426147
ENST00000507079
D6RH30
Show all »
Show » Show » 198 21.9 No 0
NFKB1-005 ENSP00000420904
ENST00000511926
D6RDI9
Show all »
Show » 74 8.7 No 0
NFKB1-007 ENSP00000423877
ENST00000509165
D6RC45
Show all »
Show » Show » 145 15.9 No 0
NFKB1-011 ENSP00000424815
ENST00000508584
D6RF93
Show all »
Show » Show » 196 21.4 No 0
NFKB1-013 ENSP00000469340
ENST00000600343
P19838
Show all »
Show » Show » 788 85.5 No 0