AREG

GENE INFORMATION

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Gene name

AREG (HGNC Symbol)

Synonyms

SDGF

Description

amphiregulin (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype. [provided by RefSeq, Jul 2008]

Chromosome

4 (Chromosome progress)

Cytoband

q13.3

Chromosome location (bp)

75310851 - 75320726

Ensembl

ENSG00000109321 (version 73.37)

Entrez gene

374

UniProt

P15514 (UniProt - Evidence at protein level)

neXtProt

NX_P15514

Antibodypedia

AREG antibodies
 

PROTEIN VIEW

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AREG-001
 
AREG-002
 
AREG-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AREG-001 ENSP00000379097
ENST00000395748
P15514
Show all »
Show » Show » 252 27.9 Yes 1
AREG-002 ENSP00000421414
ENST00000502307
D6RFX5
Show all »
Show » Show » 274 30.3 Yes 1
AREG-201 ENSP00000264487
ENST00000264487
P15514
Show all »
Show » Show » 252 27.9 Yes 1