UBE2D3

GENERAL INFORMATION

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Gene name

UBE2D3

Gene description

Ubiquitin-conjugating enzyme E2D 3

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

19
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal cells showed weak to moderate nuclear membrane positivity with additional cytoplasmic immunoreactivity.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA003920
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

UBE2D3 (HGNC Symbol)

Synonyms

UbcH5C

Description

Ubiquitin-conjugating enzyme E2D 3 (HGNC Symbol)

Entrez gene summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Multiple spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q24

Chromosome location (bp)

102794383 - 102868896

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000109332 (version 78.38)

Entrez gene

7323

UniProt

P61077 (UniProt - Evidence at protein level)

neXtProt

NX_P61077

Antibodypedia

UBE2D3 antibodies


PROTEIN BROWSER

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ENST00000321805
 
ENST00000338145
 
ENST00000343106
 
ENST00000349311
 
ENST00000350435
 
ENST00000357194
 
ENST00000394801
 
ENST00000394803
 
ENST00000394804
 
ENST00000453744
 
ENST00000502404
 
ENST00000502690
 
ENST00000504211
 
ENST00000505207
 
ENST00000507845
 
ENST00000508238
 
ENST00000508249
 
ENST00000508476
 
ENST00000618836
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UBE2D3-001 ENSP00000396901
ENST00000453744
P61077
Show all »
Show » Show » 147 16.7 No 0
UBE2D3-002 ENSP00000345285
ENST00000343106
P61077
Show all »
Show » Show » 148 16.8 No 0
UBE2D3-003 ENSP00000349722
ENST00000357194
P61077
Show all »
Show » Show » 149 16.9 No 0
UBE2D3-004 ENSP00000378280
ENST00000394801
P61077
Show all »
Show » Show » 147 16.7 No 0
UBE2D3-005 ENSP00000378282
ENST00000394803
P61077
Show all »
Show » Show » 147 16.7 No 0
UBE2D3-006 ENSP00000337208
ENST00000338145
P61077
Show all »
Show » Show » 147 16.7 No 0
UBE2D3-009 ENSP00000423487
ENST00000508238
D6RA11
Show all »
Show » Show » 96 10.7 No 0
UBE2D3-010 ENSP00000421310
ENST00000508249
D6RGD0
Show all »
Show » Show » 49 5.3 No 0
UBE2D3-011 ENSP00000425762
ENST00000502690
D6RIZ3
Show all »
Show » Show » 78 8.8 No 0
UBE2D3-012 ENSP00000344069
ENST00000349311
P61077
Show all »
Show » Show » 147 16.7 No 0
UBE2D3-013 ENSP00000318494
ENST00000321805
P61077
Show all »
Show » Show » 147 16.7 No 0
UBE2D3-014 ENSP00000337262
ENST00000350435
H9KV45
Show all »
Show » Show » 141 15.9 No 0
UBE2D3-015 ENSP00000426586
ENST00000505207
D6RAH7
Show all »
Show » Show » 118 13.6 No 0
UBE2D3-016 ENSP00000424359
ENST00000507845
D6RAH7
Show all »
Show » Show » 118 13.6 No 0
UBE2D3-017 ENSP00000421904
ENST00000502404
D6RAH7
Show all »
Show » Show » 118 13.6 No 0
UBE2D3-018 ENSP00000424710
ENST00000508476
D6RAW0
Show all »
Show » Show » 72 8.2 No 0
UBE2D3-019 ENSP00000426620
ENST00000504211
D6RAH7
Show all »
Show » Show » 118 13.6 No 0
UBE2D3-201 ENSP00000378283
ENST00000394804
P61077
Show all »
Show » Show » 147 16.7 No 0
UBE2D3-202 ENSP00000481600
ENST00000618836
D6RAH7
Show all »
Show » Show » 148 16.8 No 0