MAPK10

GENE INFORMATION

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Gene name

MAPK10 (HGNC Symbol)

Synonyms

JNK3, p493F12, p54bSAPK, PRKM10

Description

mitogen-activated protein kinase 10 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

4 (Chromosome progress)

Cytoband

q21.3

Chromosome location (bp)

86936276 - 87515284

Ensembl

ENSG00000109339 (version 73.37)

Entrez gene

5602

UniProt

P53779 (UniProt - Evidence at protein level)

neXtProt

NX_P53779

Antibodypedia

MAPK10 antibodies
 

PROTEIN VIEW

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 « 
 
MAPK10-001
 
MAPK10-002
 
MAPK10-003
 
MAPK10-004
 
MAPK10-005
 
MAPK10-012
 
MAPK10-014
 
MAPK10-015
 
MAPK10-017
 
MAPK10-018
 
MAPK10-020
 
MAPK10-021
 
MAPK10-025
 
MAPK10-026
 
MAPK10-027
 
MAPK10-028
 
MAPK10-029
 
MAPK10-030
 
MAPK10-201
 
MAPK10-202
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAPK10-001 ENSP00000378598
ENST00000395169
P53779
Show all »
Show » Show » 426 48.1 No 0
MAPK10-002 ENSP00000378595
ENST00000395166
P53779
Show all »
Show » Show » 426 48.1 No 0
MAPK10-003 ENSP00000309857
ENST00000310816
A8MPV1
Show all »
Show » 143 16.1 No 0
MAPK10-004 ENSP00000378589
ENST00000395160
P53779
Show all »
Show » Show » 277 31.9 No 0
MAPK10-005 ENSP00000355297
ENST00000361569
P53779
Show all »
Show » Show » 422 48.6 No 0
MAPK10-012 ENSP00000352157
ENST00000359221
P53779
Show all »
Show » Show » 464 52.6 No 0
MAPK10-014 ENSP00000378586
ENST00000395157
A8MWW6
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Show » Show » 319 36 No 0
MAPK10-015 ENSP00000424154
ENST00000515400
B7Z1Z1
Show all »
Show » Show » 335 38.4 No 0
MAPK10-017 ENSP00000420987
ENST00000513186
D6RDG1
Show all »
Show » 48 5.6 No 0
MAPK10-018 ENSP00000423918
ENST00000502302
D6RC26
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Show » 33 3.8 No 0
MAPK10-020 ENSP00000421409
ENST00000503911
D6RFX8
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Show » 51 6 No 0
MAPK10-021 ENSP00000421762
ENST00000511328
D6RAJ0
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Show » 117 13.4 No 0
MAPK10-025 ENSP00000425654
ENST00000512689
D6RJF9
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Show » 52 5.7 No 0
MAPK10-026 ENSP00000421359
ENST00000506773
D6RFZ7
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Show » 91 10.2 No 0
MAPK10-027 ENSP00000424755
ENST00000512017
D6RAU3
Show all »
Show » 141 16.2 No 0
MAPK10-028 ENSP00000422985
ENST00000512564
D6R9C1
Show all »
Show » 84 9.5 No 0
MAPK10-029 ENSP00000422277
ENST00000511167
D6RCB1
Show all »
Show » 121 13.8 No 0
MAPK10-030 ENSP00000424128
ENST00000509464
D6RBH2
Show all »
Show » 74 8.3 No 0
MAPK10-201 ENSP00000378590
ENST00000395161
P53779
Show all »
Show » Show » 422 48.6 No 0
MAPK10-202 ENSP00000414469
ENST00000449047
Q499Y8
Show all »
Show » Show » 319 35.7 No 0