FBXW7

GENE INFORMATION

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Gene name

FBXW7 (HGNC Symbol)

Synonyms

AGO, CDC4, FBW7, FBX30, FBXW6, FLJ11071, SEL-10, SEL10

Description

F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]

Chromosome

4 (Chromosome progress)

Cytoband

q31.3

Chromosome location (bp)

153242410 - 153457253

Ensembl

ENSG00000109670 (version 73.37)

Entrez gene

55294

UniProt

Q969H0 (UniProt - Evidence at protein level)

neXtProt

NX_Q969H0

Antibodypedia

FBXW7 antibodies
 

PROTEIN VIEW

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FBXW7-001
 
FBXW7-002
 
FBXW7-003
 
FBXW7-004
 
FBXW7-005
 
FBXW7-007
 
FBXW7-012
 
FBXW7-013
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FBXW7-001 ENSP00000281708
ENST00000281708
Q969H0
Show all »
Show » Show » 707 79.7 No 0
FBXW7-002 ENSP00000474725
ENST00000603548
H9CWI3
Show all »
Show » Show » 707 79.7 No 0
FBXW7-003 ENSP00000296555
ENST00000296555
Q969H0
Show all »
Show » Show » 589 66.1 No 0
FBXW7-004 ENSP00000474751
ENST00000604872
G0Z2K0
Show all »
Show » 176 20 No 0
FBXW7-005 ENSP00000263981
ENST00000263981
Q969H0
Show all »
Show » Show » 627 70.3 No 0
FBXW7-007 ENSP00000377528
ENST00000393956
B7Z2C8
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Show » Show » 531 59.7 Yes 0
FBXW7-012 ENSP00000474971
ENST00000603841
H9CWI3
Show all »
Show » Show » 707 79.7 No 0
FBXW7-013 ENSP00000474538
ENST00000605042
G0Z2K0
Show all »
Show » 158 17.9 No 0