CLNK

GENERAL INFORMATION

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Gene name

CLNK

Gene description

Cytokine-dependent hematopoietic cell linker

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (kidney)
GTEx:Tissue enhanced (kidney)

Protein evidence

Evidence at protein level

Protein localization

Selective cytoplasmic expression, most abundant in subsets of leukocytes.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA035671 , HPA035672
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (kidney)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (kidney)

Organ

Expression



GENE INFORMATION

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Gene name

CLNK (HGNC Symbol)

Synonyms

MIST

Description

Cytokine-dependent hematopoietic cell linker (HGNC Symbol)

Entrez gene summary

MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).[supplied by OMIM, Mar 2008]

Chromosome

4

Cytoband

p16.1

Chromosome location (bp)

10486395 - 10684865

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000109684 (version 78.38)

Entrez gene

116449

UniProt

Q7Z7G1 (UniProt - Evidence at protein level)

neXtProt

NX_Q7Z7G1

Antibodypedia

CLNK antibodies


PROTEIN BROWSER

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ENST00000226951
 
ENST00000442825
 
ENST00000507719
 
ENST00000515667
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CLNK-001 ENSP00000226951
ENST00000226951
Q7Z7G1
Show all »
Show » Show » 428 49.6 No 0
CLNK-002 ENSP00000427208
ENST00000507719
Q7Z7G1
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Show » Show » 169 19.4 No 0
CLNK-003 ENSP00000427256
ENST00000515667
D6RJB9
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Show » 166 19.5 No 0
CLNK-201 ENSP00000390744
ENST00000442825
D6RJB9
Show all »
Show » 428 49.5 No 0