RAPGEF2

GENE INFORMATION

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Gene name

RAPGEF2 (HGNC Symbol)

Synonyms

DKFZP586O1422, KIAA0313, PDZ-GEF1, PDZGEF1, RA-GEF

Description

Rap guanine nucleotide exchange factor (GEF) 2 (HGNC Symbol)

Entrez gene summary

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]

Chromosome

4 (Chromosome progress)

Cytoband

q32.1

Chromosome location (bp)

160025330 - 160281321

Ensembl

ENSG00000109756 (version 73.37)

Entrez gene

9693

UniProt

Q9Y4G8 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y4G8

Antibodypedia

RAPGEF2 antibodies
 

PROTEIN VIEW

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RAPGEF2-001
 
RAPGEF2-003
 
RAPGEF2-006
 
RAPGEF2-007
 
RAPGEF2-008
 
RAPGEF2-009
 
RAPGEF2-010
 
RAPGEF2-011
 
RAPGEF2-013
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RAPGEF2-001 ENSP00000264431
ENST00000264431
Q9Y4G8
Show all »
Show » 1499 167.4 No 0
RAPGEF2-003 ENSP00000422707
ENST00000505478
H0Y905
Show all »
Show » 279 31.9 No 0
RAPGEF2-006 ENSP00000422361
ENST00000514565
D6RC78
Show all »
Show » 154 17 No 0
RAPGEF2-007 ENSP00000421602
ENST00000511336
D6REY8
Show all »
Show » 116 13 No 0
RAPGEF2-008 ENSP00000421740
ENST00000510510
D6RAK0
Show all »
Show » 155 17.2 No 0
RAPGEF2-009 ENSP00000422098
ENST00000502485
182 20.1 No 0
RAPGEF2-010 ENSP00000421083
ENST00000510253
Show » 266 28.6 No 0
RAPGEF2-011 ENSP00000427334
ENST00000505026
324 34.5 No 0
RAPGEF2-013 ENSP00000421624
ENST00000512056
Show » 189 20.8 No 0