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GENE INFORMATION

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Gene name

PPARGC1A (HGNC Symbol)

Synonyms

PGC1, PGC1A, PPARGC1

Description

peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]

Chromosome

4 (Chromosome progress)

Cytoband

p15.2

Chromosome location (bp)

23756664 - 23905712

Ensembl

ENSG00000109819 (version 69.37)

Entrez gene

10891

UniProt

Q9UBK2

neXtProt

NX_Q9UBK2

Antibodypedia

PPARGC1A antibodies
 

PROTEIN VIEW

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PPARGC1A-001
 
PPARGC1A-004
 
PPARGC1A-007
 
PPARGC1A-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PPARGC1A-001 ENSP00000264867
ENST00000264867
Q9UBK2
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Show » Show » 798 91 No 0
PPARGC1A-004 ENSP00000424181
ENST00000507380
D6RBF3
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99 11.2 No 0
PPARGC1A-007 ENSP00000423075
ENST00000506055
Q3LIG1
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271 30 No 0
PPARGC1A-008 ENSP00000421632
ENST00000513205
B7Z406
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Show » 301 33.2 No 0