The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
Renal cancers and a few cases of malignant gliomas, thyroid, endometrial and ovarian cancers displayed moderate cytoplasmic staining. Remaining malignant tissues were in general negative.
Most malignant cells showed moderate to strong cytoplasmic positivity with granular pattern. Several cases or malignant lymphomas, lung, cervical and urothelial were weakly stained or negative.
Strong cytoplasmic positivity was observed in renal cancers, malignant gliomas and melanomas. Thyroid cancers along with a few cases of ovarian, endometrial, lung and skin cancers showed moderate to strong cytoplasmic immunoreactivity. Malignant cells in general were negative.
Validation
Two (or more) antibodies yielding partly similar staining patterns which are consistent with gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are consistent with gene/protein characterization data
