CRYAB

GENE INFORMATION

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Gene name

CRYAB (HGNC Symbol)

Synonyms

CRYA2, HSPB5

Description

crystallin, alpha B (HGNC Symbol)

Entrez gene summary

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

q23.1

Chromosome location (bp)

111779289 - 111794446

Ensembl

ENSG00000109846 (version 73.37)

Entrez gene

1410

UniProt

P02511 (UniProt - Evidence at protein level)

neXtProt

NX_P02511

Antibodypedia

CRYAB antibodies
 

PROTEIN VIEW

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 « 
 
CRYAB-001
 
CRYAB-002
 
CRYAB-003
 
CRYAB-004
 
CRYAB-005
 
CRYAB-006
 
CRYAB-007
 
CRYAB-008
 
CRYAB-009
 
CRYAB-010
 
CRYAB-011
 
CRYAB-012
 
CRYAB-013
 
CRYAB-014
 
CRYAB-015
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CRYAB-001 ENSP00000436051
ENST00000526180
P02511
Show all »
Show » Show » 175 20.2 No 0
CRYAB-002 ENSP00000433560
ENST00000533475
P02511
Show all »
Show » Show » 175 20.2 No 0
CRYAB-003 ENSP00000227251
ENST00000227251
P02511
Show all »
Show » Show » 175 20.2 No 0
CRYAB-004 ENSP00000434269
ENST00000533971
E9PRA8
Show all »
Show » Show » 155 17.9 No 1
CRYAB-005 ENSP00000436089
ENST00000527899
E9PR44
Show all »
Show » 174 20 No 0
CRYAB-006 ENSP00000435931
ENST00000533879
E9PRS4
Show all »
Show » 69 8.2 No 0
CRYAB-007 ENSP00000432182
ENST00000528628
E9PS12
Show all »
Show » 77 9.2 No 0
CRYAB-008 ENSP00000435411
ENST00000525823
E9PNH7
Show all »
Show » 108 12.3 No 0
CRYAB-009 ENSP00000435960
ENST00000528961
E9PNH7
Show all »
Show » 108 12.3 No 0
CRYAB-010 ENSP00000434793
ENST00000526167
E9PNH7
Show all »
Show » 106 12 No 0
CRYAB-011 ENSP00000435046
ENST00000533280
E9PNH7
Show all »
Show » 108 12.3 No 0
CRYAB-012 ENSP00000432454
ENST00000524660
106 11.7 No 0
CRYAB-013 ENSP00000437149
ENST00000527950
P02511
Show all »
Show » Show » 175 20.2 No 0
CRYAB-014 ENSP00000431754
ENST00000529647
E9PJL7
Show all »
Show » 130 15.4 No 0
CRYAB-015 ENSP00000434247
ENST00000531198
P02511
Show all »
Show » Show » 175 20.2 No 0