CTSC

GENERAL INFORMATION

? »

Gene name

CTSC

Gene description

Cathepsin C

Protein class

Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Expressed in all
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression with a granular a pattern.

ANTIBODY RELIABILITY

? »

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
CAB025364
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

? »

Gene name

CTSC (HGNC Symbol)

Synonyms

DPP1, PALS, PLS

Description

Cathepsin C (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q14.2

Chromosome location (bp)

88293592 - 88337787

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000109861 (version 78.38)

Entrez gene

1075

UniProt

P53634 (UniProt - Evidence at protein level)

neXtProt

NX_P53634

Antibodypedia

CTSC antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000227266
 
ENST00000524463
 
ENST00000527018
 
ENST00000528020
 
ENST00000529974
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CTSC-001 ENSP00000227266
ENST00000227266
P53634
Show all »
Show » Show » 463 51.9 Yes 0
CTSC-002 ENSP00000432541
ENST00000524463
P53634
Show all »
Show » Show » 137 15.2 Yes 0
CTSC-003 ENSP00000433539
ENST00000529974
P53634
Show all »
Show » Show » 141 15.7 Yes 0
CTSC-004 ENSP00000432556
ENST00000527018
I3V9T0
Show all »
Show » Show » 245 27.8 No 0
CTSC-009 ENSP00000433229
ENST00000528020
Show » 36 4.1 No 0