CTSC

GENE INFORMATION

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Gene name

CTSC (HGNC Symbol)

Synonyms

DPP1, PALS, PLS

Description

cathepsin C (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

q14.2

Chromosome location (bp)

88026760 - 88070955

Ensembl

ENSG00000109861 (version 73.37)

Entrez gene

1075

UniProt

P53634 (UniProt - Evidence at protein level)

neXtProt

NX_P53634

Antibodypedia

CTSC antibodies
 

PROTEIN VIEW

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CTSC-001
 
CTSC-002
 
CTSC-003
 
CTSC-004
 
CTSC-009
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CTSC-001 ENSP00000227266
ENST00000227266
P53634
Show all »
Show » Show » 463 51.9 Yes 0
CTSC-002 ENSP00000432541
ENST00000524463
P53634
Show all »
Show » Show » 137 15.2 Yes 0
CTSC-003 ENSP00000433539
ENST00000529974
P53634
Show all »
Show » Show » 141 15.7 Yes 0
CTSC-004 ENSP00000432556
ENST00000527018
I3V9T0
Show all »
Show » 245 27.8 No 0
CTSC-009 ENSP00000433229
ENST00000528020
Show » 36 4.1 No 0