CCND1

GENE INFORMATION

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Gene name

CCND1 (HGNC Symbol)

Synonyms

BCL1, D11S287E, PRAD1, U21B31

Description

cyclin D1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

q13.3

Chromosome location (bp)

69455855 - 69469242

Ensembl

ENSG00000110092 (version 73.37)

Entrez gene

595

UniProt

P24385 (UniProt - Evidence at protein level)

neXtProt

NX_P24385

Antibodypedia

CCND1 antibodies
 

PROTEIN VIEW

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CCND1-001
 
CCND1-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCND1-001 ENSP00000227507
ENST00000227507
P24385
Show all »
Show » Show » 295 33.7 No 0
CCND1-004 ENSP00000438482
ENST00000536559
F5H437
Show all »
Show » 67 7.8 No 0