DDX6

GENERAL INFORMATION

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Gene name

DDX6

Gene description

DEAD (Asp-Glu-Ala-Asp) box helicase 6

Protein class

Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression, with highest levels in the gastrointestinal tract.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA024201 , HPA026644 , CAB004668
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

DDX6 (HGNC Symbol)

Synonyms

HLR2, RCK

Description

DEAD (Asp-Glu-Ala-Asp) box helicase 6 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012]

Chromosome

11

Cytoband

q23.3

Chromosome location (bp)

118747766 - 118791149

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000110367 (version 78.38)

Entrez gene

1656

UniProt

P26196 (UniProt - Evidence at protein level)

neXtProt

NX_P26196

Antibodypedia

DDX6 antibodies


PROTEIN BROWSER

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ENST00000526070
 
ENST00000534980
 
ENST00000617381
 
ENST00000620157
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DDX6-001 ENSP00000442266
ENST00000534980
P26196
Show all »
Show » Show » 483 54.4 No 0
DDX6-002 ENSP00000433704
ENST00000526070
P26196
Show all »
Show » Show » 483 54.4 No 0
DDX6-201 ENSP00000483902
ENST00000617381
Q8IV96
Show all »
Show » Show » 187 20.4 No 0
DDX6-202 ENSP00000478754
ENST00000620157
P26196
Show all »
Show » Show » 483 54.4 No 0