CBL

GENE INFORMATION

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Gene name

CBL (HGNC Symbol)

Synonyms

c-Cbl, CBL2, RNF55

Description

Cbl proto-oncogene, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012]

Chromosome

11 (Chromosome progress)

Cytoband

q23.3

Chromosome location (bp)

119076752 - 119178859

Ensembl

ENSG00000110395 (version 73.37)

Entrez gene

867

UniProt

P22681 (UniProt - Evidence at protein level)

neXtProt

NX_P22681

Antibodypedia

CBL antibodies
 

PROTEIN VIEW

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CBL-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CBL-001 ENSP00000264033
ENST00000264033
P22681
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