CARS

GENERAL INFORMATION

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Gene name

CARS

Gene description

Cysteinyl-tRNA synthetase

Protein class

Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in most tissues. Most abundant in exocrine pancreas and neuronal cells.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 6 antibodies.
HPA002383 , HPA002384 , CAB075734 , CAB075735 , CAB075736 , CAB075737
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

CARS (HGNC Symbol)

Synonyms

CARS1

Description

Cysteinyl-tRNA synthetase (HGNC Symbol)

Entrez gene summary

This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010]

Chromosome

11

Cytoband

p15.4

Chromosome location (bp)

3000922 - 3057613

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000110619 (version 78.38)

Entrez gene

833

UniProt

P49589 (UniProt - Evidence at protein level)

neXtProt

NX_P49589

Antibodypedia

CARS antibodies


PROTEIN BROWSER

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ENST00000278224
 
ENST00000380525
 
ENST00000397111
 
ENST00000529772
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CARS-001 ENSP00000380300
ENST00000397111
P49589
Show all »
Show » Show » 748 85.5 No 0
CARS-002 ENSP00000278224
ENST00000278224
P49589
Show all »
Show » Show » 726 82.8 No 0
CARS-004 ENSP00000369897
ENST00000380525
P49589
Show all »
Show » Show » 831 94.6 No 0
CARS-016 ENSP00000432619
ENST00000529772
B4DKY1
Show all »
Show » Show » 739 84.3 No 0