NDUFS8

GENE INFORMATION

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Gene name

NDUFS8 (HGNC Symbol)

Synonyms

CI-23k, TYKY

Description

NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) (HGNC Symbol)

Entrez gene summary

This gene encodes a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of the respiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria. The encoded protein is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, as such, is required in the electron transfer process. Mutations in this gene have been associated with Leigh syndrome. [provided by RefSeq, Mar 2010]

Chromosome

11 (Chromosome progress)

Cytoband

q13.2

Chromosome location (bp)

67798084 - 67804111

Ensembl

ENSG00000110717 (version 73.37)

Entrez gene

4728

UniProt

O00217 (UniProt - Evidence at protein level)

neXtProt

NX_O00217

Antibodypedia

NDUFS8 antibodies
 

PROTEIN VIEW

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NDUFS8-001
 
NDUFS8-004
 
NDUFS8-007
 
NDUFS8-008
 
NDUFS8-009
 
NDUFS8-011
 
NDUFS8-012
 
NDUFS8-013
 
NDUFS8-014
 
NDUFS8-015
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NDUFS8-001 ENSP00000315774
ENST00000313468
O00217
Show all »
Show » Show » 210 23.7 Yes 0
NDUFS8-004 ENSP00000432848
ENST00000528492
Q08E91
Show all »
Show » 64 7.4 No 0
NDUFS8-007 ENSP00000434283
ENST00000524810
93 9.9 No 0
NDUFS8-008 ENSP00000433645
ENST00000526446
E9PJY7
Show all »
43 4.4 Yes 0
NDUFS8-009 ENSP00000431293
ENST00000529645
H0YCB2
Show all »
40 4 No 0
NDUFS8-011 ENSP00000403972
ENST00000453471
F8W9K7
Show all »
Show » 124 13.9 Yes 0
NDUFS8-012 ENSP00000433054
ENST00000531228
E9PML5
Show all »
70 7.6 No 0
NDUFS8-013 ENSP00000433521
ENST00000525419
E9PKH6
Show all »
Show » 138 15.9 No 0
NDUFS8-014 ENSP00000432968
ENST00000525628
E9PN51
Show all »
Show » Show » 110 12.4 Yes 0
NDUFS8-015 ENSP00000436287
ENST00000526339
E9PPW7
Show all »
Show » 184 20.7 Yes 0