METAP2

GENE INFORMATION

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Gene name

METAP2 (HGNC Symbol)

Synonyms

MAP2, MNPEP, p67

Description

methionyl aminopeptidase 2 (HGNC Symbol)

Entrez gene summary

This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2. [provided by RefSeq, Jul 2008]

Chromosome

12 (Chromosome progress)

Cytoband

q22

Chromosome location (bp)

95867296 - 95909615

Ensembl

ENSG00000111142 (version 73.37)

Entrez gene

10988

UniProt

P50579 (UniProt - Evidence at protein level)

neXtProt

NX_P50579

Antibodypedia

METAP2 antibodies
 

PROTEIN VIEW

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METAP2-001
 
METAP2-002
 
METAP2-003
 
METAP2-004
 
METAP2-006
 
METAP2-007
 
METAP2-008
 
METAP2-010
 
METAP2-012
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

METAP2-001 ENSP00000325312
ENST00000323666
P50579
Show all »
Show » Show » 478 52.9 No 0
METAP2-002 ENSP00000261220
ENST00000261220
G3XA91
Show all »
Show » 455 50.5 No 0
METAP2-003 ENSP00000446052
ENST00000535095
G3V1U3
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Show » 328 36 No 0
METAP2-004 ENSP00000448169
ENST00000546753
B4DUX5
Show all »
Show » 455 50.5 No 0
METAP2-006 ENSP00000448614
ENST00000550777
F8VRR3
Show all »
Show » 442 48.9 No 0
METAP2-007 ENSP00000450063
ENST00000551840
F8VQZ7
Show all »
Show » 477 52.8 No 0
METAP2-008 ENSP00000448370
ENST00000549502
F8VSC4
Show all »
Show » 161 17.1 No 0
METAP2-010 ENSP00000447661
ENST00000549808
F8VZX9
Show all »
Show » 163 18.1 No 0
METAP2-012 ENSP00000449004
ENST00000553151
F8VY03
Show all »
Show » 178 19.7 No 0