CREBL2

GENE INFORMATION

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Gene name

CREBL2

Synonyms

Description

cAMP responsive element binding protein-like 2 (HGNC Symbol)

Entrez gene summary

cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008]

Chromosome

12 (Chromosome progress)

Cytoband

p13.2

Chromosome location (bp)

12764761 - 12798042

Ensembl

ENSG00000111269 (version 73.37)

Entrez gene

1389

UniProt

O60519 (UniProt - Evidence at protein level)

neXtProt

NX_O60519

Antibodypedia

CREBL2 antibodies
 

PROTEIN VIEW

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CREBL2-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CREBL2-001 ENSP00000228865
ENST00000228865
O60519
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