ALDH2

GENE INFORMATION

? »

Gene name

ALDH2

Synonyms

Description

aldehyde dehydrogenase 2 family (mitochondrial) (HGNC Symbol)

Entrez gene summary

This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011]

Chromosome

12 (Chromosome progress)

Cytoband

q24.12

Chromosome location (bp)

112204691 - 112247782

Ensembl

ENSG00000111275 (version 73.37)

Entrez gene

217

UniProt

P05091 (UniProt - Evidence at protein level)

neXtProt

NX_P05091

Antibodypedia

ALDH2 antibodies
 

PROTEIN VIEW

? »
 
 
 
ALDH2-001
 
ALDH2-003
 
ALDH2-005
 
ALDH2-007
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ALDH2-001 ENSP00000261733
ENST00000261733
P05091
Show all »
Show » Show » 517 56.4 No 0
ALDH2-003 ENSP00000403349
ENST00000416293
P05091
Show all »
Show » Show » 470 51 No 0
ALDH2-005 ENSP00000448179
ENST00000548536
F8VSB0
Show all »
79 8.8 Yes 0
ALDH2-007 ENSP00000474669
ENST00000549106
Show » 117 12.7 No 0