RFC5

GENE INFORMATION

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Gene name

RFC5 (HGNC Symbol)

Synonyms

RFC36

Description

replication factor C (activator 1) 5, 36.5kDa (HGNC Symbol)

Entrez gene summary

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9. [provided by RefSeq, May 2011]

Chromosome

12 (Chromosome progress)

Cytoband

q24.23

Chromosome location (bp)

118451393 - 118470935

Ensembl

ENSG00000111445 (version 73.37)

Entrez gene

5985

UniProt

P40937 (UniProt - Evidence at protein level)

neXtProt

NX_P40937

Antibodypedia

RFC5 antibodies
 

PROTEIN VIEW

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RFC5-001
 
RFC5-002
 
RFC5-003
 
RFC5-004
 
RFC5-006
 
RFC5-007
 
RFC5-008
 
RFC5-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RFC5-001 ENSP00000376325
ENST00000392542
P40937
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Show » 319 36.1 No 0
RFC5-002 ENSP00000408295
ENST00000454402
P40937
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Show » 340 38.5 No 0
RFC5-003 ENSP00000443187
ENST00000537315
F5H5S0
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Show » 104 11.9 No 0
RFC5-004 ENSP00000390340
ENST00000420967
C9JH72
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Show » 104 11.7 No 0
RFC5-006 ENSP00000393636
ENST00000449641
E9PEP3
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Show » 99 11.3 No 0
RFC5-007 ENSP00000445917
ENST00000484086
F5H0U6
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Show » 139 15.3 No 0
RFC5-008 ENSP00000438252
ENST00000535092
F5H304
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Show » 63 7.2 No 0
RFC5-201 ENSP00000229043
ENST00000229043
F8W9B4
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Show » 255 28.8 No 0