CHD4

GENERAL INFORMATION

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Gene name

CHD4

Gene description

Chromodomain helicase DNA binding protein 4

Protein class

Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous nuclear and cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
HPA012008
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

CHD4 (HGNC Symbol)

Synonyms

Mi-2b, Mi2-BETA

Description

Chromodomain helicase DNA binding protein 4 (HGNC Symbol)

Entrez gene summary

The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Chromosome

12

Cytoband

p13.31

Chromosome location (bp)

6570083 - 6607476

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000111642 (version 78.38)

Entrez gene

1108

UniProt

Q14839 (UniProt - Evidence at protein level)

neXtProt

NX_Q14839

Antibodypedia

CHD4 antibodies


PROTEIN BROWSER

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ENST00000357008
 
ENST00000544040
 
ENST00000544484
 
ENST00000545584
 
ENST00000545942
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CHD4-002 ENSP00000440542
ENST00000544040
F5GWX5
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Show » Show » 1905 217.1 No 0
CHD4-003 ENSP00000437506
ENST00000545942
F5H6N4
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Show » Show » 354 39.1 No 0
CHD4-004 ENSP00000444614
ENST00000545584
F5H596
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Show » Show » 125 13.8 No 0
CHD4-013 ENSP00000440392
ENST00000544484
Q14839
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Show » Show » 1937 220.5 No 0
CHD4-201 ENSP00000349508
ENST00000357008
Q14839
Show all »
Show » Show » 1912 218 No 0