PTPN6

GENE INFORMATION

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Gene name

PTPN6 (HGNC Symbol)

Synonyms

HCP, HCPH, PTP-1C, SHP-1, SHP1

Description

Protein tyrosine phosphatase, non-receptor type 6 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

p13.31

Chromosome location (bp)

6946468 - 6961316

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000111679 (version 78.38)

Entrez gene

5777

UniProt

P29350 (UniProt - Evidence at protein level)

neXtProt

NX_P29350

Antibodypedia

PTPN6 antibodies
 

PROTEIN VIEW

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PTPN6-001
 
PTPN6-008
 
PTPN6-014
 
PTPN6-018
 
PTPN6-021
 
PTPN6-023
 
PTPN6-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTPN6-001 ENSP00000382376
ENST00000399448
P29350
Show all »
Show » Show » 597 67.7 No 0
PTPN6-008 ENSP00000326010
ENST00000318974
P29350
Show all »
Show » Show » 595 67.6 No 0
PTPN6-014 ENSP00000438740
ENST00000538715
F5H0N8
Show all »
Show » 165 18.5 No 0
PTPN6-018 ENSP00000443393
ENST00000543115
F5H5H9
Show all »
Show » 130 14.6 No 0
PTPN6-021 ENSP00000440114
ENST00000542462
F5GY79
Show all »
Show » 144 16.1 No 0
PTPN6-023 ENSP00000445646
ENST00000541698
F5H1Z8
Show all »
Show » 151 17.1 No 0
PTPN6-201 ENSP00000391592
ENST00000456013
P29350
Show all »
Show » Show » 624 70.1 No 0