PTPN6

GENE INFORMATION

? »

Gene name

PTPN6 (HGNC Symbol)

Synonyms

HCP, HCPH, PTP-1C, SHP-1, SHP1

Description

Protein tyrosine phosphatase, non-receptor type 6 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

p13.31

Chromosome location (bp)

7055631 - 7070479

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000111679 (version 75.37)

Entrez gene

5777

UniProt

P29350 (UniProt - Evidence at protein level)

neXtProt

NX_P29350

Antibodypedia

PTPN6 antibodies
 

PROTEIN VIEW

? »
 
 
 « 
 
PTPN6-001
 
PTPN6-008
 
PTPN6-012
 
PTPN6-013
 
PTPN6-014
 
PTPN6-016
 
PTPN6-018
 
PTPN6-019
 
PTPN6-021
 
PTPN6-023
 
PTPN6-201
 
PTPN6-202
 
 » 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTPN6-001 ENSP00000382376
ENST00000399448
P29350
Show all »
Show » Show » 597 67.7 No 0
PTPN6-008 ENSP00000326010
ENST00000318974
P29350
Show all »
Show » Show » 595 67.6 No 0
PTPN6-012 ENSP00000476175
ENST00000545153
U3KQS1
Show all »
Show » Show » 72 7.8 No 0
PTPN6-013 ENSP00000446345
ENST00000536013
F5H1V7
Show all »
Show » Show » 56 6.1 No 0
PTPN6-014 ENSP00000438740
ENST00000538715
F5H0N8
Show all »
Show » Show » 165 18.5 No 0
PTPN6-016 ENSP00000441044
ENST00000535462
F5GXD4
Show all »
Show » Show » 60 6.8 No 0
PTPN6-018 ENSP00000443393
ENST00000543115
F5H5H9
Show all »
Show » Show » 130 14.6 No 0
PTPN6-019 ENSP00000444805
ENST00000542848
F5H4Z1
Show all »
Show » Show » 58 6.3 No 0
PTPN6-021 ENSP00000440114
ENST00000542462
F5GY79
Show all »
Show » Show » 144 16.1 No 0
PTPN6-023 ENSP00000445646
ENST00000541698
F5H1Z8
Show all »
Show » Show » 151 17.1 No 0
PTPN6-201 ENSP00000415979
ENST00000447931
P29350
Show all »
Show » Show » 556 63.1 No 0
PTPN6-202 ENSP00000391592
ENST00000456013
P29350
Show all »
Show » Show » 624 70.1 No 0