MAPK14

GENE INFORMATION

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Gene name

MAPK14 (HGNC Symbol)

Synonyms

CSBP1, CSBP2, CSPB1, Mxi2, p38, PRKM14, PRKM15

Description

mitogen-activated protein kinase 14 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

6 (Chromosome progress)

Cytoband

p21.31

Chromosome location (bp)

35995488 - 36079013

Ensembl

ENSG00000112062 (version 73.37)

Entrez gene

1432

UniProt

Q16539 (UniProt - Evidence at protein level)

neXtProt

NX_Q16539

Antibodypedia

MAPK14 antibodies
 

PROTEIN VIEW

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MAPK14-001
 
MAPK14-002
 
MAPK14-003
 
MAPK14-004
 
MAPK14-006
 
MAPK14-007
 
MAPK14-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAPK14-001 ENSP00000229795
ENST00000229795
Q16539
Show all »
Show » Show » 360 41.5 No 0
MAPK14-002 ENSP00000229794
ENST00000229794
Q16539
Show all »
Show » Show » 360 41.3 No 0
MAPK14-003 ENSP00000419837
ENST00000468133
B4E0K5
Show all »
Show » Show » 283 32.4 No 0
MAPK14-004 ENSP00000308669
ENST00000310795
Q16539
Show all »
Show » Show » 307 35.5 No 0
MAPK14-006 ENSP00000417531
ENST00000491957
B5TY33
Show all »
Show » 173 19.9 No 0
MAPK14-007 ENSP00000419141
ENST00000472333
E7EX54
Show all »
Show » 133 15.5 No 0
MAPK14-008 ENSP00000417065
ENST00000474429
Show » 90 10.1 No 0