MRPL18

GENE INFORMATION

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Gene name

MRPL18 (HGNC Symbol)

Synonyms

HSPC071

Description

mitochondrial ribosomal protein L18 (HGNC Symbol)

Entrez gene summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L18P ribosomal protein family. Three polymorphic sites exist in this gene, one of which is three nt in length which causes an extra aa near the N-terminus. [provided by RefSeq, Jul 2008]

Chromosome

6 (Chromosome progress)

Cytoband

q25.3

Chromosome location (bp)

160210844 - 160219468

Ensembl

ENSG00000112110 (version 73.37)

Entrez gene

29074

UniProt

Q9H0U6 (UniProt - Evidence at protein level)

neXtProt

NX_Q9H0U6

Antibodypedia

MRPL18 antibodies
 

PROTEIN VIEW

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MRPL18-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MRPL18-001 ENSP00000356001
ENST00000367034
Q9H0U6
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