The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Most normal tissues displayed weak to moderate cytoplasmic positivity in cases combined with nucleolar staining. Cells in seminiferous ducts showed strong nuclear immunoreactivity. Strong cytoplasmic and membranous positivity was observed in the intestine and gall bladder. Alveolar cell, liver, bone marrow, glial cells and most lymphoid cells were negative.
Breast, urothelium, pancreatic ducts and salivary gland ducts showed strong cytoplasmic and membranous staining while respiratory epithelia along with trophoblastic cells exhibited moderate positivity. Purkinje cells displayed strong cytoplasmic immunoreactivity. Remaining normal tissues were in general weakly stained or negative.
Most of the normal tissues displayed moderate to strong cytoplasmic and membranous positivity. Nuclear staining was observed in neuronal cells and seminiferous duct cells. Alveolar cells, hepatocytes, endocrine glands, glial cells, lymphoid tissues and myocytes were negative.
Most normal tissues displayed moderate cytoplasmic positivity with additional membranous staining in several cases. Respiratory epithelia, squamous epithelia, placental trophoblasts, renal tubules, glial cells and subsets of neurons were strongly stained. Spleen and bone marrow poietic cells were negative.