BAG2

GENERAL INFORMATION

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Gene name

BAG2

Gene description

BCL2-associated athanogene 2

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (smooth muscle)
GTEx:Tissue enhanced (endometrium)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in subsets of tissues including muscle, lymphoid germinal center cells and testis.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA018862 , HPA019918
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Smooth muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (smooth muscle)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (endometrium)

Organ

Expression



GENE INFORMATION

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Gene name

BAG2

Synonyms

Description

BCL2-associated athanogene 2 (HGNC Symbol)

Entrez gene summary

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p12.1

Chromosome location (bp)

57172326 - 57189833

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000112208 (version 78.38)

Entrez gene

9532

UniProt

O95816 (UniProt - Evidence at protein level)

neXtProt

NX_O95816

Antibodypedia

BAG2 antibodies


PROTEIN BROWSER

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ENST00000370693
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BAG2-001 ENSP00000359727
ENST00000370693
O95816
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