MRPL2

GENERAL INFORMATION

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Gene name

MRPL2

Gene description

Mitochondrial ribosomal protein L2

Protein class

Mitochondrial proteins
Predicted secreted proteins
Ribosomal proteins

Predicted localization

Secreted

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Moderate to strong staining which often showed a granular pattern was generally observed in the cytoplasm of normal cells.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA007455
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

MRPL2 (HGNC Symbol)

Synonyms

CGI-22, MRP-L14, RPML14

Description

Mitochondrial ribosomal protein L2 (HGNC Symbol)

Entrez gene summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL2 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 12q. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

Chromosome

6

Cytoband

p21.1

Chromosome location (bp)

43054029 - 43059806

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000112651 (version 78.38)

Entrez gene

51069

UniProt

Q5T653 (UniProt - Evidence at protein level)

neXtProt

NX_Q5T653

Antibodypedia

MRPL2 antibodies


PROTEIN BROWSER

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ENST00000230413
 
ENST00000388752
 
ENST00000468957
 
ENST00000487429
 
ENST00000489623
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MRPL2-001 ENSP00000373404
ENST00000388752
Q5T653
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Show » Show » 305 33.3 Yes 0
MRPL2-002 ENSP00000419710
ENST00000468957
C9JZW2
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Show » Show » 96 10.3 Yes 0
MRPL2-003 ENSP00000417101
ENST00000487429
C9J5E0
Show all »
Show » 94 10 Yes 0
MRPL2-006 ENSP00000419753
ENST00000489623
C9JZG7
Show all »
Show » Show » 103 11.1 Yes 0
MRPL2-007 ENSP00000230413
ENST00000230413
C9IY40
Show all »
Show » Show » 225 24.4 Yes 0