MRPL2

GENE INFORMATION

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Gene name

MRPL2 (HGNC Symbol)

Synonyms

CGI-22, MRP-L14, RPML14

Description

mitochondrial ribosomal protein L2 (HGNC Symbol)

Entrez gene summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL2 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 12q. [provided by RefSeq, Jul 2008]

Chromosome

6 (Chromosome progress)

Cytoband

p21.1

Chromosome location (bp)

43021767 - 43027544

Ensembl

ENSG00000112651 (version 73.37)

Entrez gene

51069

UniProt

Q5T653 (UniProt - Evidence at protein level)

neXtProt

NX_Q5T653

Antibodypedia

MRPL2 antibodies
 

PROTEIN VIEW

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MRPL2-001
 
MRPL2-002
 
MRPL2-003
 
MRPL2-006
 
MRPL2-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MRPL2-001 ENSP00000373404
ENST00000388752
Q5T653
Show all »
Show » Show » 305 33.3 Yes 0
MRPL2-002 ENSP00000419710
ENST00000468957
C9JZW2
Show all »
Show » 96 10.3 Yes 0
MRPL2-003 ENSP00000417101
ENST00000487429
C9J5E0
Show all »
94 10 Yes 0
MRPL2-006 ENSP00000419753
ENST00000489623
C9JZG7
Show all »
Show » 103 11.1 Yes 0
MRPL2-007 ENSP00000230413
ENST00000230413
C9IY40
Show all »
Show » 225 24.4 Yes 0