GMDS

GENE INFORMATION

? »

Gene name

GMDS (HGNC Symbol)

Synonyms

GMD, SDR3E1

Description

GDP-mannose 4,6-dehydratase (HGNC Symbol)

Entrez gene summary

GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]

Chromosome

6 (Chromosome progress)

Cytoband

p25.3

Chromosome location (bp)

1624041 - 2245926

Ensembl

ENSG00000112699 (version 73.37)

Entrez gene

2762

UniProt

O60547 (UniProt - Evidence at protein level)

neXtProt

NX_O60547

Antibodypedia

GMDS antibodies
 

PROTEIN VIEW

? »
 
 
 
GMDS-001
 
GMDS-007
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GMDS-001 ENSP00000370194
ENST00000380815
O60547
Show all »
Show » Show » 372 41.9 No 0
GMDS-007 ENSP00000436726
ENST00000530927
O60547
Show all »
Show » Show » 342 39.1 No 0