SENP6

GENE INFORMATION

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Gene name

SENP6 (HGNC Symbol)

Synonyms

KIAA0797, SUSP1

Description

SUMO1/sentrin specific peptidase 6 (HGNC Symbol)

Entrez gene summary

Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]

Chromosome

6 (Chromosome progress)

Cytoband

q14.1

Chromosome location (bp)

76311225 - 76427997

Ensembl

ENSG00000112701 (version 73.37)

Entrez gene

26054

UniProt

Q9GZR1 (UniProt - Evidence at protein level)

neXtProt

NX_Q9GZR1

Antibodypedia

SENP6 antibodies
 

PROTEIN VIEW

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SENP6-001
 
SENP6-002
 
SENP6-003
 
SENP6-004
 
SENP6-007
 
SENP6-010
 
SENP6-011
 
SENP6-201
 
SENP6-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SENP6-001 ENSP00000425624
ENST00000493959
D6RJH1
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Show » 74 8.1 No 0
SENP6-002 ENSP00000359027
ENST00000370010
Q9GZR1
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Show » Show » 1105 125.3 No 0
SENP6-003 ENSP00000426480
ENST00000483859
D6RG09
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220 24.8 No 0
SENP6-004 ENSP00000402527
ENST00000447266
Q9GZR1
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Show » Show » 1112 126.1 No 0
SENP6-007 ENSP00000391426
ENST00000424947
H0Y4F4
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Show » 582 65.7 No 0
SENP6-010 ENSP00000321820
ENST00000327284
F8W6D9
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Show » 685 76.9 No 0
SENP6-011 ENSP00000422576
ENST00000503501
B3KMM0
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Show » 388 45 No 0
SENP6-201 ENSP00000359031
ENST00000370014
E7EQN6
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Show » Show » 1112 126.1 No 0
SENP6-202 ENSP00000441715
ENST00000541192
B3KMM0
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Show » 368 42.8 No 0