TTK

GENE INFORMATION

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Gene name

TTK (HGNC Symbol)

Synonyms

CT96, MPH1, MPS1, MPS1L1

Description

TTK protein kinase (HGNC Symbol)

Entrez gene summary

This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

Chromosome

6 (Chromosome progress)

Cytoband

q14.1

Chromosome location (bp)

80713604 - 80752244

Ensembl

ENSG00000112742 (version 73.37)

Entrez gene

7272

UniProt

P33981 (UniProt - Evidence at protein level)

neXtProt

NX_P33981

Antibodypedia

TTK antibodies
 

PROTEIN VIEW

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TTK-001
 
TTK-002
 
TTK-003
 
TTK-004
 
TTK-005
 
TTK-006
 
TTK-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TTK-001 ENSP00000358813
ENST00000369798
P33981
Show all »
Show » Show » 857 97.1 No 0
TTK-002 ENSP00000230510
ENST00000230510
P33981
Show all »
Show » Show » 856 96.9 No 0
TTK-003 ENSP00000422936
ENST00000509894
P33981
Show all »
Show » Show » 856 96.9 No 0
TTK-004 ENSP00000421636
ENST00000511260
D6REX1
Show all »
Show » 150 17.1 No 0
TTK-005 ENSP00000424851
ENST00000502580
D6RF82
Show all »
Show » 139 15.8 No 0
TTK-006 ENSP00000427483
ENST00000504040
D6RIC6
Show all »
Show » 176 19.9 No 0
TTK-007 ENSP00000421406
ENST00000509313
D6RFY1
Show all »
Show » 79 9.3 No 0