HARS2

GENE INFORMATION

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Gene name

HARS2 (HGNC Symbol)

Synonyms

HARSL, HARSR, HO3

Description

histidyl-tRNA synthetase 2, mitochondrial (HGNC Symbol)

Entrez gene summary

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes likely share a bidirectional promoter. Mutations in this gene are associated with the pathogenesis of Perrault syndrome, which involves ovarian dysgenesis and sensorineural hearing loss. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Chromosome

5 (Chromosome progress)

Cytoband

q31.3

Chromosome location (bp)

140071011 - 140078889

Ensembl

ENSG00000112855 (version 73.37)

Entrez gene

23438

UniProt

P49590 (UniProt - Evidence at protein level)

neXtProt

NX_P49590

Antibodypedia

HARS2 antibodies
 

PROTEIN VIEW

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HARS2-001
 
HARS2-002
 
HARS2-003
 
HARS2-004
 
HARS2-008
 
HARS2-009
 
HARS2-012
 
HARS2-201
 
HARS2-202
 
HARS2-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HARS2-001 ENSP00000230771
ENST00000230771
P49590
Show all »
Show » Show » 506 56.9 Yes 0
HARS2-002 ENSP00000423530
ENST00000510104
D6R9M5
Show all »
99 10.8 Yes 0
HARS2-003 ENSP00000423616
ENST00000508522
B4DDY8
Show all »
Show » 481 54.1 Yes 0
HARS2-004 ENSP00000407105
ENST00000448069
B4DQ67
Show all »
Show » 334 37.2 Yes 0
HARS2-008 ENSP00000424516
ENST00000503873
D6RB22
Show all »
Show » 116 12.9 Yes 0
HARS2-009 ENSP00000425695
ENST00000509299
D6RJE6
Show all »
Show » 181 20.6 Yes 0
HARS2-012 ENSP00000429220
ENST00000520095
D6R9M5
Show all »
99 10.8 Yes 0
HARS2-201 ENSP00000415007
ENST00000432671
C9JHI8
Show all »
Show » 392 43.6 Yes 0
HARS2-202 ENSP00000412887
ENST00000435019
C9JV49
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Show » 466 52.4 Yes 0
HARS2-203 ENSP00000411708
ENST00000437649
E9PG66
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Show » 432 48.1 Yes 0