The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
A majority of malignancies showed weak to moderate cytoplasmic positivity. A few hepatocellular carcinomas were strongly stained. Malignant gliomas, lymphomas, melanomas and skin cancers were generally negative.
Hepatocellular carcinomas and colorectal cancers along with several squamous cell carcinomas, urothelial, pancreatic, breast and gastric cancers showed moderate to strong cytoplasmic staining with additional nuclear and/or membranous immunoreactivity in a few cases. Remaining cancers were weakly stained or negative.
Most of the malignant cells displayed moderate to strong cytoplasmic and nuclear immunoreactivity. Malignant gliomas and melanomas as well as thyroid and renal cancers along with several cases of malignant lymphomas were negative.
Validation
Two (or more) antibodies yielding partly similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
