APBB3

GENERAL INFORMATION

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Gene name

APBB3

Gene description

Amyloid beta (A4) precursor protein-binding, family B, member 3

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (cerebral cortex)
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Moderate to strong cytoplasmic positivity was observed in lymphoid tissues and in a fraction of neuronal cells in CNS. Basement membranes were stained in several cases including squamous epithelia. Other normal tissues were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA005571
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (cerebral cortex)

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

APBB3 (HGNC Symbol)

Synonyms

FE65L2

Description

Amyloid beta (A4) precursor protein-binding, family B, member 3 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta-amyloid precursor protein (APP) as well as to other APP-like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q31.3

Chromosome location (bp)

140558268 - 140593752

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000113108 (version 78.38)

Entrez gene

10307

UniProt

O95704 (UniProt - Evidence at protein level)

neXtProt

NX_O95704

Antibodypedia

APBB3 antibodies


PROTEIN BROWSER

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ENST00000354402
 
ENST00000356738
 
ENST00000357560
 
ENST00000358580
 
ENST00000412920
 
ENST00000511201
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APBB3-001 ENSP00000349177
ENST00000356738
O95704
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Show » Show » 491 53 No 0
APBB3-002 ENSP00000346378
ENST00000354402
O95704
Show all »
Show » Show » 493 53.2 No 0
APBB3-003 ENSP00000350171
ENST00000357560
O95704
Show all »
Show » Show » 486 52.6 No 0
APBB3-011 ENSP00000402591
ENST00000412920
O95704
Show all »
Show » Show » 484 52.3 No 0
APBB3-012 ENSP00000424317
ENST00000511201
D6RBA1
Show all »
Show » Show » 337 36.9 No 0
APBB3-201 ENSP00000351389
ENST00000358580
E7EX91
Show all »
Show » Show » 339 37.2 No 0