HMGCR

GENE INFORMATION

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Gene name

HMGCR

Synonyms

Description

3-hydroxy-3-methylglutaryl-CoA reductase (HGNC Symbol)

Entrez gene summary

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Chromosome

5 (Chromosome progress)

Cytoband

q13.3

Chromosome location (bp)

74632154 - 74657929

Ensembl

ENSG00000113161 (version 73.37)

Entrez gene

3156

UniProt

P04035 (UniProt - Evidence at protein level)

neXtProt

NX_P04035

Antibodypedia

HMGCR antibodies
 

PROTEIN VIEW

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HMGCR-001
 
HMGCR-002
 
HMGCR-004
 
HMGCR-005
 
HMGCR-006
 
HMGCR-009
 
HMGCR-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HMGCR-001 ENSP00000287936
ENST00000287936
P04035
Show all »
Show » Show » 888 97.5 No 8
HMGCR-002 ENSP00000426745
ENST00000511206
P04035
Show all »
Show » Show » 888 97.5 No 8
HMGCR-004 ENSP00000340816
ENST00000343975
P04035
Show all »
Show » Show » 835 92 No 8
HMGCR-005 ENSP00000421378
ENST00000509085
Show » Show » 165 17.4 No 0
HMGCR-006 ENSP00000420871
ENST00000511986
H0Y8F6
Show all »
Show » Show » 115 12.3 No 0
HMGCR-009 ENSP00000427340
ENST00000507942
D6RIW0
Show all »
Show » Show » 111 12.7 No 3
HMGCR-010 ENSP00000409100
ENST00000442032
C9JKX7
Show all »
Show » 18 2.2 No 0