IL12B

GENE INFORMATION

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Gene name

IL12B (HGNC Symbol)

Synonyms

CLMF, CLMF2, IL-12B, NKSF, NKSF2

Description

interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (HGNC Symbol)

Entrez gene summary

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]

Chromosome

5 (Chromosome progress)

Cytoband

q33.3

Chromosome location (bp)

158741791 - 158757895

Ensembl

ENSG00000113302 (version 73.37)

Entrez gene

3593

UniProt

P29460 (UniProt - Evidence at protein level)

neXtProt

NX_P29460

Antibodypedia

IL12B antibodies
 

PROTEIN VIEW

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IL12B-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL12B-001 ENSP00000231228
ENST00000231228
P29460
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